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NPM1 mutations are known to result in aberrant cytoplasmic localization and downregulation of the NPM1 protein 28 , as observed in our data (log 2 fold change (FC): 0.44, P 0.2 for C3, C7 and C8)

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substitution with Glu is likely to stabilize the -helix as well

Preprint at medRxiv (2023)

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185 To circumvent resistance and expand the scope of DDR targeting, next-generation agents such as ATR, CHK1, WEE1, and DNA-PK inhibitors are being investigated, both as monotherapies and in combination with DNA-damaging agents